Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.54 |
| ▸ | NPC1 | O15118 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.49 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.48 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.48 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | CASP1 | P29466 | 1/20 | 0.47 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.47 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.45 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.45 |
| ▸ | PTPRC | P08575 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625062 | 0.92 | HPGD (0.57) | HPGDSMN1; SMN2NPC1ARRAB9A | |
| SCHEMBL5726108 | 0.84 | HPGD (0.57) | HPGDSMN1; SMN2LMNAKDM4EGRIN1 | |
| SCHEMBL14368556 | 0.82 | TDP1 (0.61) | SMN1; SMN2NPC1RAB9ALMNAHDAC1 | |
| SCHEMBL8692925 | 0.82 | HTT (0.54) | HPGDSMN1; SMN2NPC1ARRAB9A | |
| SCHEMBL7907147 | 0.80 | KDM4E (0.58) | HPGDSMN1; SMN2LMNAHDAC1KDM4E | |
| SCHEMBL14793821 | 0.80 | TRPV1 (0.57) | SMN1; SMN2LMNAHDAC1HDAC8CASP1 | |
| SCHEMBL19007852 | 0.78 | ALDH1A1 (0.59) | SMN1; SMN2LMNAHDAC1HDAC8CASP1 | |
| SCHEMBL31329294 | 0.78 | ALDH1A1 (0.61) | NPC1RAB9ATDP1ALOX5ALDH1A1 | |
| SCHEMBL9625116 | 0.77 | MAOB (0.56) | SMN1; SMN2NPC1RAB9ALMNAHDAC1 | |
| SCHEMBL19007857 | 0.76 | MAPT (0.62) | HDAC1TDP1ALOX5ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |