Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | CASP1 | P29466 | 1/20 | 0.51 |
| ▸ | MAOA | P21397 | 2/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.50 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.50 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.50 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6159752 | 0.91 | TDP1 (0.64) | MAOBMAPK1TDP1ALDH1A1L3MBTL1 | |
| SCHEMBL14368556 | 0.91 | TDP1 (0.61) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 | |
| SCHEMBL14793821 | 0.88 | TRPV1 (0.57) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 | |
| SCHEMBL19007852 | 0.85 | ALDH1A1 (0.59) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 | |
| SCHEMBL19007857 | 0.84 | MAPT (0.62) | MAPK1TDP1ALDH1A1L3MBTL1HDAC1 | |
| SCHEMBL7907176 | 0.84 | FFAR1 (0.66) | ALOX5MGLL | |
| SCHEMBL16377282 | 0.83 | TDP1 (0.53) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 | |
| SCHEMBL31329294 | 0.82 | ALDH1A1 (0.61) | TDP1ALDH1A1L3MBTL1KMT2ANPC1 | |
| SCHEMBL3868132 | 0.82 | TRPV1 (0.53) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 | |
| SCHEMBL15888217 | 0.82 | CASP1 (0.49) | MAPK1TDP1ALDH1A1L3MBTL1CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |