Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRB3 | P13945 | 2/20 | 0.43 |
| ▸ | PLA2G7 | Q13093 | 6/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.35 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.34 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.34 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.34 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22000403 | 0.81 | LIPG (0.47) | PLA2G7L3MBTL1PTGS1PTGS2KEAP1 | |
| SCHEMBL9624560 | 0.79 | KDM4E (0.48) | ADRB3PTGS2ALDH1A1CACNA1FCHRM2 | |
| SCHEMBL9626253 | 0.78 | HTR6 (0.44) | ADRB3PTGS1NR3C1CACNA1FCHRM2 | |
| SCHEMBL9624948 | 0.78 | ADRB3 (0.55) | ADRB3PLA2G7L3MBTL1PTGS2CACNA1F | |
| SCHEMBL9625827 | 0.76 | KDM4E (0.50) | ADRB3PTGS2ALDH1A1CACNA1FCHRM2 | |
| SCHEMBL3715386 | 0.75 | PLA2G7 (0.54) | PLA2G7L3MBTL1PTGS1KEAP1NR3C1 | |
| SCHEMBL9624807 | 0.75 | KDM4E (0.49) | PTGS2ALDH1A1CACNA1FCHRM2ADRA2B | |
| Bromide SCHEMBL10531026 | 0.74 | KDM4E (0.48) | PTGS2ALDH1A1CACNA1FCHRM2ADRA2B | |
| Hydrochloric Acid SCHEMBL10531414 | 0.74 | KDM4E (0.48) | PTGS2ALDH1A1CACNA1FCHRM2ADRA2B | |
| SCHEMBL7647398 | 0.74 | TAAR1 (0.50) | PLA2G7L3MBTL1PTGS1KEAP1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | claimed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | claimed |
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |