Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMPD1 | P17405 | 2/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.34 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.33 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | MAOB | P27338 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625402 | 0.96 | HDAC6 (0.34) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624484 | 0.87 | HCN4 (0.51) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9623723 | 0.82 | HCN4 (0.46) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9623778 | 0.82 | EDNRB (0.36) | MAPTHCN4CYP3A4ALOX15ALDH1A1 | |
| SCHEMBL9624774 | 0.81 | HDAC6 (0.36) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624476 | 0.81 | MAPT (0.38) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624873 | 0.80 | HDAC6 (0.35) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624575 | 0.80 | CES2 (0.35) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9624201 | 0.79 | CHRNA7 (0.42) | MAPTHCN4CYP3A4ALOX15SMPD1 | |
| SCHEMBL9625187 | 0.79 | HDAC6 (0.36) | MAPTHCN4CYP3A4ALOX15SMPD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |