Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.63 |
| ▸ | HPGD | P15428 | 3/20 | 0.51 |
| ▸ | GRIN1 | Q05586 | 7/20 | 0.46 |
| ▸ | GRIN2B | Q13224 | 7/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.46 |
| ▸ | RAB9A | P51151 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | NCOR2 | Q9Y618 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625631 | 0.85 | KDM4E (0.58) | KDM4EHPGDGRIN1GRIN2BNPC1 | |
| SCHEMBL7998829 | 0.83 | GRIN1 (0.63) | KDM4EGRIN1GRIN2BKCNH2 | |
| SCHEMBL9625004 | 0.82 | KDM4E (0.59) | KDM4EHPGDGRIN1GRIN2BNPC1 | |
| SCHEMBL3336139 | 0.81 | KDM4E (0.73) | KDM4EHPGDGRIN1GRIN2BNPC1 | |
| SCHEMBL9624530 | 0.81 | KDM4E (0.58) | KDM4EHPGDGRIN1GRIN2BNPC1 | |
| SCHEMBL10528894 | 0.78 | KCNH2 (0.57) | KDM4EHPGDNPC1RAB9AALDH1A1 | |
| SCHEMBL16976564 | 0.78 | KDM4E (0.65) | KDM4EHPGDGRIN1GRIN2BNPC1 | |
| SCHEMBL3125931 | 0.77 | POLB (0.58) | HPGDLTB4R2HDAC3HDAC1HDAC2 | |
| SCHEMBL7907147 | 0.76 | KDM4E (0.58) | KDM4EHPGDGRIN1GRIN2BALDH1A1 | |
| SCHEMBL5726108 | 0.76 | HPGD (0.57) | KDM4EHPGDGRIN1GRIN2BALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |