Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 3/20 | 0.44 |
| ▸ | DRD5 | P21918 | 3/20 | 0.44 |
| ▸ | DRD3 | P35462 | 3/20 | 0.44 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.39 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625690 | 0.97 | SMN1; SMN2 (0.48) | SMN1; SMN2KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL9624884 | 0.93 | SMN1; SMN2 (0.51) | SMN1; SMN2KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL9625527 | 0.86 | L3MBTL1 (0.38) | SMN1; SMN2MAOBPOLBALDH1A1SMPD1 | |
| SCHEMBL9624246 | 0.83 | HCN4 (0.46) | KDM4EALOX15TSHRDRD2DRD5 | |
| SCHEMBL9624619 | 0.83 | SMN1; SMN2 (0.37) | SMN1; SMN2POLB | |
| Hydrochloric Acid SCHEMBL9624740 | 0.82 | ALOX15 (0.47) | KDM4EALOX15TSHRDRD2DRD5 | |
| SCHEMBL9624134 | 0.81 | L3MBTL1 (0.38) | SMN1; SMN2DRD3HTR1AMAOBPOLB | |
| SCHEMBL9623994 | 0.81 | KDM4E (0.43) | SMN1; SMN2KDM4EALOX15TSHRSIRT1 | |
| SCHEMBL9624441 | 0.81 | L3MBTL1 (0.37) | SMN1; SMN2POLBALDH1A1HDAC6 | |
| SCHEMBL9625089 | 0.80 | HDAC6 (0.37) | SMN1; SMN2KDM4EMAOBPOLBALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |