Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.62 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.62 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.62 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | HTR2A | P28223 | 1/20 | 0.62 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.62 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.62 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.62 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.50 |
| ▸ | THRA | P10827 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9624737 | 0.99 | CACNA1F (0.61) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL9624937 | 0.90 | KDM4E (0.52) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL9625720 | 0.89 | CACNA1F (0.64) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| Hydrochloric Acid SCHEMBL9625546 | 0.88 | CACNA1F (0.63) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL9624429 | 0.84 | HDAC3 (0.57) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL10645163 | 0.82 | KCNH2 (0.61) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL9625076 | 0.81 | THRA (0.58) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL10920006 | 0.81 | KCNH2 (0.60) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| SCHEMBL9625141 | 0.80 | THRA (0.52) | CHRM2SLC6A4DRD3KCNH2CACNA1F | |
| Phosphoric Acid SCHEMBL10417638 | 0.79 | KCNH2 (0.58) | CHRM2SLC6A4DRD3KCNH2CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |