Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRA | P10827 | 7/20 | 0.58 |
| ▸ | THRB | P10828 | 6/20 | 0.58 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.50 |
| ▸ | DRD3 | P35462 | 2/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.50 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.50 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.50 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.50 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625720 | 0.90 | CACNA1F (0.64) | THRATHRBPTGS2KDM4ECHRM2 | |
| Hydrochloric Acid SCHEMBL9625546 | 0.89 | CACNA1F (0.63) | THRATHRBPTGS2KDM4ECHRM2 | |
| SCHEMBL9624937 | 0.88 | KDM4E (0.52) | THRATHRBPTGS2KDM4ECHRM2 | |
| SCHEMBL10643227 | 0.82 | KDM4E (0.55) | THRBKDM4ECHRM2SLC6A4DRD3 | |
| SCHEMBL11818687 | 0.81 | THRA (0.65) | THRATHRBKDM4EHPGDRECQL | |
| SCHEMBL9624837 | 0.81 | CHRM2 (0.62) | THRATHRBPTGS2KDM4ECHRM2 | |
| Hydrochloric Acid SCHEMBL11815733 | 0.80 | GSR (0.66) | THRATHRBKDM4EHPGDRECQL | |
| Hydrochloric Acid SCHEMBL9624737 | 0.80 | CACNA1F (0.61) | THRATHRBPTGS2KDM4ECHRM2 | |
| SCHEMBL9447401 | 0.78 | HPGD (0.54) | THRATHRBPTGS2KDM4EHPGD | |
| SCHEMBL9625141 | 0.78 | THRA (0.52) | THRATHRBPTGS2KDM4ECHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |