Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.44 |
| ▸ | POLB | P06746 | 2/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | RIN1 | Q13671 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | RECQL | P46063 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625460 | 0.90 | SMN1; SMN2 (0.39) | MAPTPOLBABL1RIN1TDP1 | |
| SCHEMBL9627031 | 0.87 | SMN1; SMN2 (0.50) | POLBTDP1KDM4ELMNAALDH1A1 | |
| SCHEMBL9625448 | 0.84 | L3MBTL1 (0.40) | MAPTTSHRLMNAALDH1A1KMT2A | |
| SCHEMBL9625561 | 0.84 | ERN1 (0.43) | LMNARAB9AMAPK1NPSR1 | |
| SCHEMBL9456810 | 0.84 | MAPT (0.40) | MAPTPOLBABL1RIN1TDP1 | |
| SCHEMBL9456814 | 0.84 | MAPT (0.40) | MAPTPOLBABL1RIN1TDP1 | |
| SCHEMBL9626334 | 0.83 | POLB (0.34) | MAPTPOLBABL1RIN1TDP1 | |
| SCHEMBL12320612 | 0.82 | MAPT (0.42) | MAPTPOLBABL1RIN1TDP1 | |
| SCHEMBL9625616 | 0.82 | SMN1; SMN2 (0.33) | MAPTPOLBTSHRGAALMNA | |
| SCHEMBL9625440 | 0.80 | MEN1 (0.56) | MAPTGAAALDH1A1KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1436298-B1 | HIMBACINE ANALOGUES AS THROMBIN RECEPTOR ANTAGONISTS | SCHERING CORP (US) | 2011-09-21 | — | — | EP | disclosed |
| EP-0308283-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0308283-A1 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |