Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.33 |
| ▸ | GAA | P10253 | 4/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.32 |
| ▸ | RAB9A | P51151 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 2/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9457289 | 0.86 | CHRM2 (0.35) | KMT2AMEN1MAPK1ALDH1A1RAB9A | |
| SCHEMBL9625460 | 0.84 | SMN1; SMN2 (0.39) | SMN1; SMN2GAAKMT2AMEN1MAPK1 | |
| SCHEMBL9624898 | 0.82 | MAPT (0.44) | SMN1; SMN2GAAKMT2AMEN1MAPK1 | |
| SCHEMBL9627031 | 0.82 | SMN1; SMN2 (0.50) | SMN1; SMN2KMT2AMEN1ALDH1A1POLB | |
| SCHEMBL9626334 | 0.81 | POLB (0.34) | SMN1; SMN2GAAKMT2AMEN1MAPK1 | |
| SCHEMBL9625448 | 0.76 | L3MBTL1 (0.40) | SMN1; SMN2KMT2AMEN1MAPK1ALDH1A1 | |
| SCHEMBL9626076 | 0.76 | OPRM1 (0.47) | SMN1; SMN2KMT2AMEN1ALDH1A1RAB9A | |
| SCHEMBL9625561 | 0.76 | ERN1 (0.43) | MAPK1RAB9ANPSR1LMNA | |
| SCHEMBL9625440 | 0.73 | MEN1 (0.56) | SMN1; SMN2GAAKMT2AMEN1ALDH1A1 | |
| SCHEMBL9626054 | 0.72 | GPR119 (0.35) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0308283-B1 | 1,2,5,6-TETRAHYDROPYRIDINE-3-CARBOXALDEHYDE OXIME DERIVATIVES, PROCESS FOR THEIR PREPARATION, THEIR USE AS PHARMACEUTICAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM | ROUSSEL-UCLAF (FR) | 1992-01-22 | — | — | EP | disclosed |
| EP-0308283-A1 | 1,2,5,6-Tetrahydropyridine-3-carboxaldehyde oxime derivatives, process for their preparation, their use as pharmaceutical compounds and compositions containing them | ROUSSEL-UCLAF (FR) | 1989-03-22 | — | — | EP | disclosed |