Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | HCN4 | Q9Y3Q4 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.32 |
| ▸ | CTSL | P07711 | 1/20 | 0.32 |
| ▸ | NAAA | Q02083 | 1/20 | 0.32 |
| ▸ | BCHE | P06276 | 2/20 | 0.31 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | LTA4H | P09960 | 1/20 | 0.30 |
| ▸ | MAOA | P21397 | 1/20 | 0.30 |
| ▸ | ACHE | P22303 | 1/20 | 0.30 |
| ▸ | MAOB | P27338 | 1/20 | 0.30 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10401291 | 0.95 | NAAA (0.36) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9625000 | 0.87 | CNR2 (0.39) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624670 | 0.85 | CYP3A4 (0.34) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624078 | 0.82 | MAPT (0.39) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624416 | 0.81 | KDM4E (0.34) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624338 | 0.81 | SIGMAR1 (0.34) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624644 | 0.79 | DRD2 (0.33) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9624412 | 0.79 | KDM4E (0.34) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9625002 | 0.79 | DRD2 (0.33) | MAPTHCN4CYP3A4ALOX15KDM4E | |
| SCHEMBL9625302 | 0.79 | MAPT (0.36) | MAPTHCN4CYP3A4ALOX15KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |