Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 2/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.43 |
| ▸ | MAOB | P27338 | 4/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 5/20 | 0.38 |
| ▸ | DHPS | P49366 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9624201 | 0.91 | CHRNA7 (0.42) | KDM4EALDH1A1DHPS | |
| SCHEMBL10644226 | 0.91 | CHRNA7 (0.40) | KDM4EALDH1A1DHPS | |
| SCHEMBL10401085 | 0.90 | KDM4E (0.42) | CHRNB2CHRNA4MAOBKDM4EALDH1A1 | |
| SCHEMBL9623977 | 0.87 | MAOA (0.43) | CHRNB2CHRNA4MAOBKDM4EALDH1A1 | |
| Hydrochloric Acid SCHEMBL9625013 | 0.86 | CYP3A4 (0.42) | CHRNB2CHRNA4MAOBKDM4EALDH1A1 | |
| SCHEMBL9624387 | 0.81 | MAPT (0.39) | KDM4EALDH1A1DHPS | |
| SCHEMBL9625087 | 0.81 | MAPT (0.43) | KDM4EALDH1A1DHPS | |
| SCHEMBL9624248 | 0.80 | HDAC6 (0.35) | MAOBKDM4EALDH1A1 | |
| SCHEMBL9624753 | 0.78 | MAPT (0.45) | KDM4EALDH1A1LMNA | |
| SCHEMBL9624907 | 0.78 | MAPT (0.49) | KDM4EALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |