Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | CNR2 | P34972 | 3/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8695595 | 0.86 | CNR2 (0.72) | TDP1CNR2KMT2AMEN1POLB | |
| SCHEMBL1856691 | 0.78 | CNR2 (0.72) | CNR2KMT2AMEN1POLB | |
| SCHEMBL1852549 | 0.78 | CNR2 (0.72) | CNR2KMT2AMEN1POLB | |
| SCHEMBL31616456 | 0.77 | CNR2 (0.70) | CNR2KMT2AMEN1POLB | |
| SCHEMBL24244093 | 0.75 | CNR2 (0.44) | TDP1CNR2KMT2AMEN1KDM4E | |
| SCHEMBL7193360 | 0.74 | CNR1 (0.51) | TDP1CNR2KMT2AMEN1ALDH1A1 | |
| SCHEMBL8626174 | 0.74 | MEN1 (0.50) | TDP1CNR2KMT2AMEN1KDM4E | |
| SCHEMBL18896343 | 0.74 | POLB (0.69) | TDP1CNR2KMT2AMEN1CYP1A2 | |
| SCHEMBL11045634 | 0.73 | HTR2A (0.44) | KMT2AMEN1KDM4ESMN1; SMN2HIF1A | |
| SCHEMBL7828211 | 0.73 | PLA2G2C (0.63) | KMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155268-A | Antiarrhythmic N-aminoalkylene alkyl and aryl sulfonamides | THE UPJOHN COMPANY (US) | 1992-10-13 | — | — | US | disclosed |
| EP-0164865-B1 | N-(AMINOALKYLPHENYL)SULFONAMIDES THEIR PREPARATION AND THERAPEUTIC USE | THE UPJOHN COMPANY (US) | 1988-12-21 | — | — | EP | disclosed |
| EP-0164865-A1 | N-(Aminoalkylphenyl)sulfonamides their preparation and therapeutic use | THE UPJOHN COMPANY (US) | 1985-12-18 | — | — | EP | disclosed |