Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TERT | O14746 | 1/20 | 0.41 |
| ▸ | S100B | P04271 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 15/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 7/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.37 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.37 |
| ▸ | RECQL | P46063 | 3/20 | 0.37 |
| ▸ | GFER | P55789 | 3/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | PSMD14 | O00487 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 8/20 | 0.36 |
| ▸ | MEN1 | O00255 | 7/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 7/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.35 |
| ▸ | ALDH1A3 | P47895 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.35 |
| ▸ | GLA | P06280 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625629 | 0.80 | ALDH1A1 (0.37) | TERTALDH1A1MAPK1CYP3A4TDP1 | |
| SCHEMBL11028260 | 0.70 | TERT (0.48) | TERTS100BALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL208170 | 0.70 | GFER (0.33) | ALDH1A1MAPK1TDP1GFERMAPT | |
| SCHEMBL9624198 | 0.66 | ALDH1A1 (0.35) | ALDH1A1L3MBTL1MAPK1CYP3A4TDP1 | |
| SCHEMBL207512 | 0.66 | CYP2A6 (0.35) | — | |
| SCHEMBL9624098 | 0.66 | NOX1 (0.31) | — | |
| SCHEMBL5538925 | 0.66 | EPHX2 (0.39) | ALDH1A1MAPK1TSHRHSD17B10HPGD | |
| SCHEMBL11868826 | 0.66 | TERT (0.49) | TERTS100BALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL1735497 | 0.65 | ALDH1A1 (0.74) | TERTS100BALDH1A1L3MBTL1MAPK1 | |
| SCHEMBL16288692 | 0.63 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |