Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.37 |
| ▸ | TSHR | P16473 | 4/20 | 0.37 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.37 |
| ▸ | APP | P05067 | 5/20 | 0.35 |
| ▸ | TERT | O14746 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 4/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.32 |
| ▸ | THRB | P10828 | 3/20 | 0.32 |
| ▸ | RECQL | P46063 | 3/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | APAF1 | O14727 | 2/20 | 0.32 |
| ▸ | GSR | P00390 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 2/20 | 0.32 |
| ▸ | PKM | P14618 | 2/20 | 0.32 |
| ▸ | MAOA | P21397 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9625533 | 0.80 | TERT (0.41) | ALDH1A1TSHRALOX15HSD17B10TERT | |
| SCHEMBL207512 | 0.69 | CYP2A6 (0.35) | — | |
| SCHEMBL9624198 | 0.69 | ALDH1A1 (0.35) | ALDH1A1TSHRALOX15HSD17B10MAPT | |
| SCHEMBL9624098 | 0.69 | NOX1 (0.31) | — | |
| SCHEMBL5538925 | 0.65 | EPHX2 (0.39) | ALDH1A1TSHRHSD17B10MAPK1KDM4E | |
| SCHEMBL827260 | 0.64 | APP (0.47) | ALDH1A1TSHRALOX15HSD17B10APP | |
| SCHEMBL16288692 | 0.63 | — | — | |
| SCHEMBL1147598 | 0.61 | APP (0.39) | ALDH1A1TSHRALOX15HSD17B10APP | |
| SCHEMBL6357105 | 0.61 | ALDH1A1 (0.37) | ALDH1A1TSHRALOX15HSD17B10APP | |
| SCHEMBL926598 | 0.61 | TDP1 (0.47) | ALDH1A1ALOX15HSD17B10APPTERT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | claimed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | claimed |
| US-5175157-A | Cardiovascular disorders | BOEHRINGER INGELHEIM GMBH (DE) | 1992-12-29 | — | — | US | disclosed |
| US-5116986-A | HETEROAROMATIC AMINE DERIVATIVES | DR. KARL THOMAE GMBH (DE) | 1992-05-26 | — | — | US | disclosed |
| US-4912115-A | Cardiovascular disorders | DR. KARL THOMAE GMBH (DE) | 1990-03-27 | — | — | US | disclosed |