Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 8/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.59 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.59 |
| ▸ | TSHR | P16473 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | NR3C1 | P04150 | 5/20 | 0.58 |
| ▸ | PGR | P06401 | 3/20 | 0.58 |
| ▸ | AR | P10275 | 3/20 | 0.58 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 2/20 | 0.45 |
| ▸ | SERPINA6 | P08185 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627206 | 1.00 | HIF1A (0.59) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11432685 | 0.92 | HIF1A (0.58) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11432675 | 0.92 | HIF1A (0.58) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11807661 | 0.91 | HIF1A (0.56) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11807654 | 0.91 | HIF1A (0.56) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11311611 | 0.90 | PGR (0.68) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11311598 | 0.90 | PGR (0.68) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11313619 | 0.90 | PGR (0.68) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11417094 | 0.88 | ABCB11 (0.70) | HIF1ACYP3A4CYP2C9HSD17B10TSHR | |
| SCHEMBL11417086 | 0.88 | ABCB11 (0.70) | HIF1ACYP3A4CYP2C9HSD17B10TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | claimed |
| US-4898693-A | Process for production of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-4-pregnene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | claimed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | claimed |
| EP-0276393-B1 | PROCESS FOR THE PREPARATION OF 6-ALPHA, 9-ALPHA-DIFLUORO-11-BETA-17-ALPHA-DIHYDROXY-16-ALPHA-METHYL-PREGN-4-ENE-3,20-DIONE AND ITS DERIVATIVES | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-03-04 | — | — | EP | disclosed |
| US-4898693-A | Process for production of 6α,9α-difluoro-11β,17α-dihydroxy-16α-methyl-4-pregnene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1990-02-06 | — | — | US | disclosed |
| EP-0276393-A2 | Process for the preparation of 6-alpha, 9-alpha-difluoro-11-beta-17-alpha-dihydroxy-16-alpha-methyl-pregn-4-ene-3,20-dione and its derivatives | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-08-03 | — | — | EP | disclosed |