Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | RECQL | P46063 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | ESR1 | P03372 | 5/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.53 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 1/20 | 0.53 |
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.53 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.53 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.53 |
| ▸ | STS | P08842 | 7/20 | 0.44 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8938753 | 0.96 | LMNA (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL9628223 | 0.87 | LMNA (0.57) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8959369 | 0.85 | ESR1 (0.53) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL514373 | 0.85 | ESR1 (0.53) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL29500480 | 0.85 | ESR1 (0.53) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8056788 | 0.84 | LMNA (0.51) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8056155 | 0.84 | LMNA (0.53) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8959377 | 0.84 | LMNA (0.55) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL8959370 | 0.84 | LMNA (0.55) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 | |
| SCHEMBL9148144 | 0.84 | LMNA (0.55) | LMNAHSD17B1MAPTRECQLSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318490-B1 | 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-01-29 | — | — | EP | claimed |
| US-4789671-A | ESTROGENIC ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-12-06 | — | — | US | claimed |
| EP-0318490-B1 | 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-01-29 | — | — | EP | disclosed |
| US-4789671-A | ESTROGENIC ACTIVITY | SCHERING AKTIENGESELLSCHAFT (DE) | 1988-12-06 | — | — | US | disclosed |