Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.31 |
| ▸ | LCK | P06239 | 1/20 | 0.31 |
| ▸ | FYN | P06241 | 1/20 | 0.31 |
| ▸ | SUCNR1 | Q9BXA5 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid SCHEMBL1651901 | 0.87 | LMNA (0.62) | LMNAALDH1A1TSHRFGFR4 | |
| Methacrylic Acid SCHEMBL18886616 | 0.82 | ALDH1A1 (0.38) | LMNAALDH1A1TSHRFFAR3LCK | |
| SCHEMBL149858 | 0.80 | — | — | |
| SCHEMBL28824417 | 0.80 | — | — | |
| Acrylamide SCHEMBL28851370 | 0.78 | ALDH1A1 (0.65) | LMNAALDH1A1TSHRFGFR4 | |
| SCHEMBL6524921 | 0.78 | ALDH1A1 (0.41) | LMNAALDH1A1 | |
| Ethylene SCHEMBL14880425 | 0.76 | — | — | |
| Hydrochloric Acid SCHEMBL10323216 | 0.76 | — | — | |
| SCHEMBL9179530 | 0.73 | — | — | |
| Bicarbonate SCHEMBL325796 | 0.72 | LMNA (0.50) | LMNAALDH1A1CA1CA2CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158854-A | Ladder polymers having hydrophilic groups | NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) | 1992-10-27 | — | — | US | claimed |
| EP-0232167-B1 | PHOTOSENSITIVE AND HIGH ENERGY BEAM SENSITIVE RESIN COMPOSITION CONTAINING SUBSTITUTED POLYSILOXANE | NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) | 1988-12-28 | — | — | EP | claimed |
| EP-0232167-A2 | Photosensitive and high energy beam sensitive resin composition containing substituted polysiloxane | NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) | 1987-08-12 | — | — | EP | claimed |