Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 12/20 | 0.53 |
| ▸ | NQO2 | P16083 | 11/20 | 0.53 |
| ▸ | MTNR1B | P49286 | 11/20 | 0.53 |
| ▸ | DRD2 | P14416 | 3/20 | 0.52 |
| ▸ | DRD3 | P35462 | 3/20 | 0.52 |
| ▸ | DRD4 | P21917 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627859 | 0.90 | GRIN1 (0.46) | MTNR1ANQO2MTNR1BDRD2DRD3 | |
| SCHEMBL9628081 | 0.82 | ACHE (0.60) | — | |
| SCHEMBL2421262 | 0.81 | MTNR1A (0.65) | MTNR1ANQO2MTNR1B | |
| SCHEMBL11647146 | 0.81 | MTNR1A (0.62) | MTNR1ANQO2MTNR1B | |
| SCHEMBL9627819 | 0.81 | ADRA2A (0.57) | MTNR1ANQO2MTNR1BDRD2DRD3 | |
| SCHEMBL8432456 | 0.81 | ADRA2A (0.50) | DRD2DRD3DRD4 | |
| SCHEMBL10467975 | 0.80 | MTNR1A (0.55) | MTNR1ANQO2MTNR1B | |
| SCHEMBL9628479 | 0.80 | ACHE (0.44) | MTNR1ANQO2MTNR1B | |
| SCHEMBL9627778 | 0.79 | MCHR1 (0.48) | MTNR1ANQO2MTNR1B | |
| SCHEMBL8645028 | 0.77 | ADRA2A (0.47) | MTNR1ANQO2MTNR1BDRD2DRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |