Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.52 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | IDO1 | P14902 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 3/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629394 | 0.89 | KDM4E (0.56) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9628418 | 0.88 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9812680 | 0.88 | KDM4E (0.57) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9627337 | 0.85 | PDE4A (0.47) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9713828 | 0.84 | KDM4E (0.60) | KDM4EALDH1A1SMN1; SMN2HTTMAPT | |
| SCHEMBL9627757 | 0.84 | ALOX5 (0.46) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9629259 | 0.83 | ABCB11 (0.45) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9642268 | 0.83 | ABCB11 (0.55) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL24596049 | 0.82 | KDM4E (0.53) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B | |
| SCHEMBL9627671 | 0.81 | KDM4E (0.41) | KDM4EALDH1A1SMN1; SMN2PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |