Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | FFAR3 | O14843 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL202800 | 0.85 | — | — | |
| SCHEMBL6516287 | 0.82 | ALDH1A1 (0.35) | ALDH1A1TSHR | |
| SCHEMBL28435327 | 0.70 | TDP1 (0.45) | ALDH1A1TSHRFFAR3TDP1 | |
| Bicarbonate SCHEMBL9628099 | 0.69 | LMNA (0.41) | ALDH1A1TSHRFFAR3LMNA | |
| Bicarbonate SCHEMBL995845 | 0.69 | — | — | |
| Bicarbonate SCHEMBL7091018 | 0.69 | ALDH1A1 (0.45) | ALDH1A1TSHRFFAR3TDP1LMNA | |
| Bicarbonate SCHEMBL27811383 | 0.69 | ALDH1A1 (0.45) | ALDH1A1TSHRFFAR3TDP1LMNA | |
| SCHEMBL7770882 | 0.69 | LMNA (0.35) | ALDH1A1TSHRLMNA | |
| SCHEMBL11481556 | 0.69 | TSHR (0.32) | TSHR | |
| Bicarbonate SCHEMBL6423684 | 0.67 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5158854-A | Ladder polymers having hydrophilic groups | NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) | 1992-10-27 | — | — | US | claimed |
| EP-0232167-B1 | PHOTOSENSITIVE AND HIGH ENERGY BEAM SENSITIVE RESIN COMPOSITION CONTAINING SUBSTITUTED POLYSILOXANE | NIPPON TELEGRAPH AND TELEPHONE CORPORATION (JP) | 1988-12-28 | — | — | EP | claimed |