Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | ATM | Q13315 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | NPC1 | O15118 | 1/20 | 0.44 |
| ▸ | RAB9A | P51151 | 1/20 | 0.44 |
| ▸ | MRGPRX4 | Q96LA9 | 1/20 | 0.43 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9628298 | 0.90 | SMN1; SMN2 (0.54) | SMN1; SMN2ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL9629368 | 0.84 | HTT (0.44) | SMN1; SMN2ALDH1A1L3MBTL1KDM4ETSHR | |
| SCHEMBL9641650 | 0.82 | SMN1; SMN2 (0.61) | SMN1; SMN2ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL9660434 | 0.81 | HPGD (0.54) | SMN1; SMN2ALDH1A1L3MBTL1KDM4EHPGD | |
| SCHEMBL9659120 | 0.81 | SMN1; SMN2 (0.46) | SMN1; SMN2ALDH1A1L3MBTL1HPGDLMNA | |
| SCHEMBL9660313 | 0.81 | KDM4E (0.47) | SMN1; SMN2ALDH1A1L3MBTL1KDM4ETSHR | |
| SCHEMBL10698804 | 0.79 | HTT (0.64) | SMN1; SMN2ALDH1A1MAPTTDP1KDM4E | |
| SCHEMBL1171372 | 0.79 | L3MBTL1 (0.60) | SMN1; SMN2ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL30233793 | 0.79 | L3MBTL1 (0.60) | SMN1; SMN2ALDH1A1MAPTL3MBTL1ATM | |
| SCHEMBL9629315 | 0.78 | TOP2A (0.48) | ALDH1A1KDM4ECYP1A2CYP3A4CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |