Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 2/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | TNFSF11 | O14788 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629477 | 0.91 | HTT (0.50) | HTTALOX5 | |
| SCHEMBL9629305 | 0.89 | HTT (0.50) | HTTSMN1; SMN2ALDH1A1TNFSF11MAPT | |
| SCHEMBL9628345 | 0.89 | HTT (0.56) | HTTTNFSF11MAPTALOX5TSHR | |
| SCHEMBL9660042 | 0.88 | SMN1; SMN2 (0.43) | HTTSMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL9627936 | 0.88 | ALDH1A1 (0.43) | HTTSMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL9627873 | 0.86 | HTT (0.60) | HTTSMN1; SMN2ALDH1A1MAPTTSHR | |
| SCHEMBL9659126 | 0.86 | ALDH1A1 (0.45) | HTTSMN1; SMN2ALDH1A1MAPTRAB9A | |
| SCHEMBL9628363 | 0.85 | HTT (0.55) | HTTMAPTL3MBTL1TSHRKDM4E | |
| SCHEMBL10698804 | 0.84 | HTT (0.64) | HTTSMN1; SMN2ALDH1A1TNFSF11MAPT | |
| SCHEMBL9627465 | 0.84 | HTT (0.69) | HTTALDH1A1TNFSF11MAPTL3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |