Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 5/20 | 0.43 |
| ▸ | HMGCR | P04035 | 3/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3796995 | 1.00 | PTPN7 (0.43) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL5865499 | 1.00 | PTPN7 (0.43) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL31519146 | 1.00 | PTPN7 (0.43) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL9336077 | 1.00 | PTPN7 (0.43) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL3796992 | 1.00 | PTPN7 (0.43) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL2121918 | 0.97 | PTPN7 (0.40) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL588584 | 0.90 | TSHR (0.39) | PTPN7HMGCRTSHRTHRBRECQL | |
| SCHEMBL31725737 | 0.89 | RAB9A (0.38) | PTPN7HMGCR | |
| SCHEMBL16420274 | 0.87 | RAB9A (0.33) | — | |
| SCHEMBL29979993 | 0.84 | PTPN7 (0.50) | PTPN7HMGCRRECQLTDP1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1992021672-A1 | PLA2 INHIBITORS | G. D. SEARLE & CO. (US) | 1992-12-10 | — | — | WO | disclosed |
| EP-0515777-A1 | PLA2 inhibitors | G.D. Searle & Co. (US) | 1992-12-02 | — | — | EP | disclosed |
| US-5112864-A | Inhibitors of phospholipase enzymes by treatment with oxo alkynyl furan, thiophene or benzene carboxylic acid derivative | G. D. SEARLE & CO. (US) | 1992-05-12 | — | — | US | disclosed |