Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 10/20 | 0.43 |
| ▸ | MEN1 | O00255 | 3/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.40 |
| ▸ | HPGD | P15428 | 4/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.37 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | PARP15 | Q460N3 | 1/20 | 0.37 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.37 |
| ▸ | TNKS2 | Q9H2K2 | 1/20 | 0.37 |
| ▸ | TP53 | P04637 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627800 | 0.90 | ABCB11 (0.43) | ABCB11KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9628139 | 0.90 | ABCB11 (0.46) | ABCB11KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9627496 | 0.84 | CASP3 (0.48) | ABCB11KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9627547 | 0.80 | ABCB11 (0.59) | ABCB11KDM4EALDH1A1HPGDHSD17B10 | |
| SCHEMBL9628112 | 0.79 | TUBB4A (0.45) | ABCB11KDM4EMEN1KMT2AALDH1A1 | |
| SCHEMBL9642665 | 0.78 | ABCB11 (0.69) | ABCB11KDM4EKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL9629374 | 0.78 | ABCB11 (0.83) | ABCB11KDM4EHPGDHSD17B10CYP1A2 | |
| SCHEMBL9629451 | 0.77 | KDM4E (0.54) | ABCB11KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9629353 | 0.77 | ABCB11 (0.53) | ABCB11KDM4EALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL9628321 | 0.76 | KDM4E (0.50) | ABCB11KDM4EMEN1KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5155132-A | Nonsteroidal antiinflammatory agents; treating psoriasis | SYNTEX (U.S.A.) INC. (US) | 1992-10-13 | — | — | US | disclosed |
| US-5089657-A | Topical antiinflammatory agents | SYNTEX (U.S.A.) INC. (US) | 1992-02-18 | — | — | US | disclosed |
| EP-0282006-A1 | Naphtalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| EP-0282056-A2 | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-09-14 | — | — | EP | disclosed |
| US-4758587-A | Naphthalene anti-psoriatic agents | SYNTEX (U.S.A.) INC. (US) | 1988-07-19 | — | — | US | disclosed |