Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 10/20 | 0.80 |
| ▸ | LSS | P48449 | 2/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MAOB | P27338 | 1/20 | 0.50 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929250 | 0.89 | KCNH2 (1.00) | KCNH2GAA | |
| SCHEMBL9628913 | 0.87 | KCNH2 (0.76) | KCNH2LSSGAAMAOB | |
| SCHEMBL9628264 | 0.84 | KCNH2 (0.58) | KCNH2MAOB | |
| SCHEMBL10721556 | 0.80 | KCNH2 (0.62) | KCNH2 | |
| SCHEMBL6573083 | 0.80 | KCNH2 (0.76) | KCNH2 | |
| SCHEMBL8789805 | 0.79 | KCNH2 (0.83) | KCNH2 | |
| SCHEMBL9630223 | 0.79 | ACHE (0.49) | KCNH2LSSTSHRGAA | |
| SCHEMBL9053806 | 0.78 | CYP3A4 (0.60) | KCNH2 | |
| SCHEMBL9628761 | 0.78 | KCNH2 (0.80) | KCNH2 | |
| SCHEMBL9630209 | 0.78 | KCNH2 (0.80) | KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108164429-B | Preparation method of dofetilide intermediate | 四川科瑞德凯华制药有限公司 | 2021-07-23 | — | — | CN | disclosed |
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |