Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 12/20 | 0.76 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | LSS | P48449 | 2/20 | 0.48 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.48 |
| ▸ | DRD3 | P35462 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PLK1 | P53350 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3929250 | 0.87 | KCNH2 (1.00) | KCNH2GAACACNA1FCHRM2ACHE | |
| SCHEMBL9628896 | 0.87 | KCNH2 (0.80) | KCNH2LSSGAAMAOB | |
| SCHEMBL9629107 | 0.84 | KCNH2 (0.54) | KCNH2RAB9ACACNA1FCHRM2ACHE | |
| Hydrochloric Acid SCHEMBL9628828 | 0.79 | KCNH2 (0.77) | KCNH2RAB9ACACNA1FCHRM2ACHE | |
| SCHEMBL9628048 | 0.78 | KCNH2 (0.80) | KCNH2RAB9ACACNA1FCHRM2ACHE | |
| SCHEMBL9630209 | 0.78 | KCNH2 (0.80) | KCNH2RAB9ACACNA1FCHRM2ACHE | |
| SCHEMBL9826975 | 0.78 | SIGMAR1 (0.70) | KCNH2MAPTRAB9A | |
| SCHEMBL8789805 | 0.77 | KCNH2 (0.83) | KCNH2ACHE | |
| SCHEMBL10721560 | 0.77 | KCNH2 (0.57) | KCNH2MAPTRAB9AACHE | |
| SCHEMBL6573083 | 0.76 | KCNH2 (0.76) | KCNH2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0245997-B1 | N-SUBSTITUTED P-AMINOETHYLSULPHON ANILIDES AS ANTIARRHYTHMIC AGENTS, AND INTERMEDIATES THEREFOR | Pfizer Limited (GB) | 1992-04-15 | — | — | EP | disclosed |
| US-5079248-A | Antifibrillatory agents; side effect reduction | PFIZER INC. (US) | 1992-01-07 | — | — | US | disclosed |
| US-4959366-A | Anti-arrhythmic agents | PFIZER INC. (US) | 1990-09-25 | — | — | US | disclosed |
| EP-0245997-A2 | N-substituted p-aminoethylsulphon anilides as antiarrhythmic agents, and intermediates therefor | Pfizer Limited (GB) | 1987-11-19 | — | — | EP | disclosed |