Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.55 |
| ▸ | DRD2 | P14416 | 2/20 | 0.45 |
| ▸ | DRD3 | P35462 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 4/20 | 0.44 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.42 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.41 |
| ▸ | HTR1D | P28221 | 1/20 | 0.41 |
| ▸ | GLS | O94925 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL9118102 | 0.83 | HRH3 (0.49) | HRH3POLBMTNR1AGABRA1GABRB2 | |
| SCHEMBL9458993 | 0.83 | HRH3 (0.47) | HRH3MTNR1AGABRA1GABRB2GLS | |
| SCHEMBL9118219 | 0.80 | HRH3 (0.46) | HRH3MTNR1AGABRA1GABRB2HTR1A | |
| Methylamine SCHEMBL10700886 | 0.80 | HRH3 (0.59) | HRH3DRD2DRD3MTNR1AGABRA1 | |
| SCHEMBL7323697 | 0.80 | HTR1A (0.61) | DRD2DRD3HTR1AHTR1D | |
| SCHEMBL9629907 | 0.79 | MTNR1A (0.52) | HRH3MTNR1AGABRA1GABRB2GLS | |
| SCHEMBL9117533 | 0.77 | HRH3 (0.63) | HRH3DRD2DRD3MTNR1AGABRA1 | |
| SCHEMBL10257134 | 0.77 | HRH3 (0.60) | HRH3POLBMTNR1AGABRA1GABRB2 | |
| SCHEMBL10256487 | 0.77 | HRH3 (0.59) | HRH3MTNR1AGABRA1GABRB2GLS | |
| SCHEMBL9627919 | 0.76 | HRH3 (0.55) | HRH3DRD2DRD3MTNR1AGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0281261-B1 | 3-AMINOMETHYL DERIVATIVES OF INDANE, INDOLINE AND DIHYDROBENZOFURANE AND DIHYDROBENZOTHIOPHENE | H. LUNDBECK A/S (DK) | 1992-05-06 | — | — | EP | disclosed |
| US-4946863-A | CNS-affecting 6-oxy-3-aminomethyl indanes, compositions thereof, and method of treating therewith | H. LUNDBECK A/S (DK) | 1990-08-07 | — | — | US | disclosed |
| US-4847254-A | CNS affecting 5-oxy-3-aminomethyl-dihydro-benzofurans and benzothiophenes | H. LUNDBECK A/S (DK) | 1989-07-11 | — | — | US | disclosed |
| EP-0281261-A2 | 3-Aminomethyl derivatives of indane, indoline and dihydrobenzofurane and dihydrobenzothiophene | H. LUNDBECK A/S (DK) | 1988-09-07 | — | — | EP | disclosed |