Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.71 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.66 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.66 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.66 |
| ▸ | L3MBTL3 | Q96JM7 | 1/20 | 0.66 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.64 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.61 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.61 |
| ▸ | MAOA | P21397 | 1/20 | 0.59 |
| ▸ | KCNJ1 | P48048 | 1/20 | 0.58 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.58 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.58 |
| ▸ | HTR2A | P28223 | 1/20 | 0.54 |
| ▸ | HTR2C | P28335 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | HTR6 | P50406 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23377646 | 0.98 | HRH3 (0.68) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL23377845 | 0.94 | HRH3 (0.62) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL6984190 | 0.89 | SCN5A (0.74) | HRH3SIGMAR1SCN5ASLC6A3HTR2A | |
| SCHEMBL22813547 | 0.86 | SCN5A (0.71) | HRH3SIGMAR1SCN5ASLC6A3HTR2A | |
| SCHEMBL5752571 | 0.83 | KCNH2 (0.64) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL5745400 | 0.82 | KCNJ1 (0.61) | HRH3SIGMAR1SLC6A3CYP1A2MAOA | |
| SCHEMBL8804098 | 0.82 | MAOA (0.67) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL23731966 | 0.82 | SCN5A (0.66) | HRH3SIGMAR1SCN5ASLC6A3HTR2A | |
| SCHEMBL13958507 | 0.82 | L3MBTL1 (0.96) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 | |
| SCHEMBL13958981 | 0.82 | L3MBTL1 (0.96) | HRH3SIGMAR1L3MBTL1MBTD1L3MBTL3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101412693-A | 4-[1-hydroxy-1-(2,3-dimethoxyphenyl)methyl]piperidine and method for preparing corresponding piperidine thereby | AVENTIS PHARMA INC (US) | 2009-04-22 | — | — | CN | disclosed |
| CN-1989119-A | New benzoyl urea derivatives | RICHTER GEDEON VEGYESZET (HU) | 2007-06-27 | — | — | CN | disclosed |
| CN-1143321-A | Treatment of obsessive-compulsive disorders with 5-HT2 antagonists | MERRELL DOW PHARMA (US) | 1997-02-19 | — | — | CN | disclosed |
| US-5134149-A | Serotonin antagonist | MERRELL DOW PHARMACEUTICALS INC. (US) | 1992-07-28 | — | — | US | disclosed |