Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | APP | P05067 | 1/20 | 0.43 |
| ▸ | THRB | P10828 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 3/20 | 0.42 |
| ▸ | RAB9A | P51151 | 3/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | AKR1C3 | P42330 | 2/20 | 0.41 |
| ▸ | ESR1 | P03372 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL423258 | 0.87 | TDP1 (0.59) | TDP1POLBABCG2THRBATM | |
| SCHEMBL28415884 | 0.85 | ABCG2 (0.52) | TDP1POLBABCG2THRBATM | |
| SCHEMBL2038405 | 0.83 | TDP1 (0.63) | TDP1POLBABCG2THRBATM | |
| SCHEMBL2038409 | 0.83 | TDP1 (0.63) | TDP1POLBABCG2THRBATM | |
| SCHEMBL28588565 | 0.81 | THRB (0.47) | TDP1POLBABCG2THRBATM | |
| SCHEMBL8081148 | 0.81 | THRB (0.49) | TDP1POLBABCG2THRBATM | |
| SCHEMBL8081146 | 0.81 | THRB (0.49) | TDP1POLBABCG2THRBATM | |
| SCHEMBL1391294 | 0.80 | TDP1 (0.56) | TDP1POLBABCG2THRBATM | |
| SCHEMBL7181303 | 0.80 | TDP1 (0.53) | TDP1POLBABCG2PLA2G4BBCHE | |
| SCHEMBL158084 | 0.79 | POLB (0.59) | POLBABCG2APPTHRBATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5100918-A | Prevention or treatment of sunburn using the S(+) isomer of ibuprofen | STERLING DRUG, INC. (US) | 1992-03-31 | — | — | US | claimed |