Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | THRB | P10828 | 1/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.47 |
| ▸ | TAS1R3 | Q7RTX0 | 2/20 | 0.46 |
| ▸ | TAS1R1 | Q7RTX1 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 3/20 | 0.44 |
| ▸ | RAB9A | P51151 | 3/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2038405 | 1.00 | TDP1 (0.63) | TDP1LMNATHRBATMABCG2 | |
| SCHEMBL423258 | 0.96 | TDP1 (0.59) | TDP1LMNATHRBATMABCG2 | |
| SCHEMBL17212259 | 0.90 | TDP1 (0.63) | TDP1LMNAABCG2TAS1R3TAS1R1 | |
| SCHEMBL29090825 | 0.90 | TDP1 (0.57) | TDP1LMNATHRBATMABCG2 | |
| SCHEMBL1391294 | 0.89 | TDP1 (0.56) | TDP1LMNATHRBATMABCG2 | |
| SCHEMBL9414106 | 0.88 | TDP1 (0.71) | TDP1LMNAABCG2TAS1R3TAS1R1 | |
| SCHEMBL10334196 | 0.88 | TDP1 (0.71) | TDP1LMNAABCG2TAS1R3TAS1R1 | |
| SCHEMBL12936605 | 0.86 | TDP1 (0.73) | TDP1LMNAABCG2TAS1R3TAS1R1 | |
| SCHEMBL8084721 | 0.86 | THRB (0.50) | TDP1THRBATMABCG2TAS1R3 | |
| SCHEMBL8084722 | 0.86 | THRB (0.50) | TDP1THRBATMABCG2TAS1R3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4942174-A | ALKOXYARYLCARBOXYLIC ACIDS OR ESTERS OR SALTS FOR SKIN DISORDERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1990-07-17 | — | — | US | claimed |
| EP-2509577-B1 | NOVEL COMPOUNDS | DSM IP ASSETS BV (NL) | 2014-08-27 | — | — | EP | disclosed |
| US-20120282201-A1 | NOVEL COMPOUNDS | DSM IP ASSETS B.V. (NL) | 2012-11-08 | — | — | US | disclosed |
| EP-2509577-A2 | NOVEL COMPOUNDS | DSM IP Assets B.V. (NL) | 2012-10-17 | — | — | EP | disclosed |
| WO-2011070075-A2 | Novel compounds | DSM IP ASSETS B.V. (NL) | 2011-06-16 | — | — | WO | disclosed |
| US-4942174-A | ALKOXYARYLCARBOXYLIC ACIDS OR ESTERS OR SALTS FOR SKIN DISORDERS | HENKEL KOMMANDITGESELLSCHAFT AUF AKTIEN (DE) | 1990-07-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120282201-A1 | NOVEL COMPOUNDS | MGLL, DGKZ, DGAT2 | TDP1 2150/4885LMNA 2921/4885THRB 2409/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.