Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 6/20 | 0.35 |
| ▸ | CCR2 | P41597 | 5/20 | 0.35 |
| ▸ | ROCK1 | Q13464 | 5/20 | 0.35 |
| ▸ | MAPT | P10636 | 9/20 | 0.35 |
| ▸ | TP53 | P04637 | 5/20 | 0.35 |
| ▸ | ENPP2 | Q13822 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630310 | 0.90 | EED (0.40) | ROCK2CCR2ROCK1MAPTTP53 | |
| SCHEMBL9631303 | 0.87 | ROCK2 (0.35) | ROCK2CCR2ROCK1TP53 | |
| SCHEMBL9629497 | 0.87 | ROCK2 (0.34) | ROCK2CCR2ROCK1MAPTTP53 | |
| SCHEMBL9691136 | 0.86 | SLC6A9 (0.44) | SLC6A9MAPTTP53ENPP2POLB | |
| SCHEMBL10548020 | 0.85 | SLC6A9 (0.53) | SLC6A9MAPTTP53ENPP2POLB | |
| SCHEMBL1152028 | 0.84 | HRH1 (0.38) | ROCK2CCR2ROCK1MAPTTP53 | |
| SCHEMBL1152449 | 0.83 | KCNH2 (0.46) | ROCK2CCR2ROCK1MAPTTP53 | |
| SCHEMBL9690741 | 0.82 | SLC6A9 (0.46) | SLC6A9MAPTTP53ENPP2POLB | |
| SCHEMBL10382581 | 0.80 | SLC6A9 (0.36) | SLC6A9ROCK2ROCK1MAPTTP53 | |
| SCHEMBL9629312 | 0.80 | SLC6A9 (0.47) | SLC6A9ROCK2CCR2ROCK1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5151424-A | Antiallergens or antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-09-29 | — | — | US | disclosed |
| US-5071846-A | Anti-hystaminic [(bicyclic heterocyclyl) methyl and --hetero] substituted hexahydro-1H-azepines and pyrrolidines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-12-10 | — | — | US | disclosed |
| US-4988689-A | Antiallergens, antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-01-29 | — | — | US | disclosed |