Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 6/20 | 1.00 |
| ▸ | PTGS1 | P23219 | 2/20 | 0.46 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | COMT | P21964 | 1/20 | 0.45 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | RELA | Q04206 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1954803 | 0.79 | ALOX5 (0.66) | ALOX5MEN1ALDH1A1GAAMAPT | |
| SCHEMBL92933 | 0.79 | ALOX5 (0.66) | ALOX5PTGS1PTGS2COMTMEN1 | |
| SCHEMBL12335757 | 0.78 | ALOX5 (0.61) | ALOX5COMTNPC1ALDH1A1LMNA | |
| SCHEMBL3138593 | 0.78 | ALOX5 (0.80) | ALOX5MEN1ALDH1A1KMT2A | |
| SCHEMBL526264 | 0.78 | PTGS2 (0.69) | ALOX5PTGS1PTGS2COMTNTRK1 | |
| SCHEMBL9628717 | 0.77 | ALOX5 (1.00) | ALOX5MEN1MAPTKMT2A | |
| SCHEMBL2091332 | 0.76 | ALOX5 (0.61) | ALOX5PTGS1PTGS2COMTNTRK1 | |
| SCHEMBL11964993 | 0.76 | ALOX5 (0.61) | ALOX5PTGS1PTGS2COMTMEN1 | |
| SCHEMBL18373459 | 0.76 | ALOX5 (0.61) | ALOX5PTGS1PTGS2COMTNTRK1 | |
| SCHEMBL80459 | 0.76 | ALOX5 (0.61) | ALOX5PTGS1PTGS2NTRK1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |