Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 4/20 | 0.68 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.63 |
| ▸ | MEN1 | O00255 | 1/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | LMNA | P02545 | 1/20 | 0.63 |
| ▸ | GAA | P10253 | 1/20 | 0.63 |
| ▸ | MAPT | P10636 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9436438 | 0.82 | ALOX5 (0.66) | ALOX5KDM4EALDH1A1MAPT | |
| SCHEMBL9629237 | 0.82 | ALOX5 (0.62) | ALOX5KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL9830647 | 0.79 | ALDH1A1 (0.56) | ALOX5KDM4EALDH1A1MAPT | |
| SCHEMBL9629266 | 0.79 | ALOX5 (0.63) | ALOX5 | |
| SCHEMBL9629483 | 0.79 | ALOX5 (0.58) | ALOX5KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL9629280 | 0.79 | MAPT (0.58) | ALOX5KDM4EMEN1ALDH1A1LMNA | |
| SCHEMBL9628607 | 0.79 | KDM4E (0.58) | KDM4EMEN1ALDH1A1LMNAGAA | |
| SCHEMBL9630548 | 0.78 | ALOX5 (0.62) | ALOX5 | |
| SCHEMBL9823302 | 0.78 | PTGDR2 (0.53) | ALOX5KDM4EALDH1A1GAAMAPT | |
| SCHEMBL9629437 | 0.78 | ALOX5 (1.00) | ALOX5KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5124342-A | Antiinflammatory, antiarthritic agents; antiallergens; skin disorders | ABBOTT LABORATORIES (US) | 1992-06-23 | — | — | US | disclosed |
| EP-0457803-A4 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | — | 1991-12-04 | — | — | EP | disclosed |
| EP-0457803-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1991-11-27 | — | — | EP | disclosed |
| WO-1990009801-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-09-07 | — | — | WO | disclosed |
| WO-1990009381-A1 | 4-HYDROXYTHIAZOLES AS 5-LIPOXYGENASE INHIBITORS | ABBOTT LABORATORIES (US) | 1990-08-23 | — | — | WO | disclosed |