Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 3/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | FNTA | P49354 | 6/20 | 0.50 |
| ▸ | FNTB | P49356 | 4/20 | 0.50 |
| ▸ | PGGT1B | P53609 | 3/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.47 |
| ▸ | UGT1A1 | P22309 | 1/20 | 0.47 |
| ▸ | SQLE | Q14534 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9629657 | 1.00 | ALOX15 (0.53) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL5320561 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL19873084 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL11851208 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL6061920 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL28008995 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL30531902 | 0.82 | KMT2A (0.70) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL9629757 | 0.81 | ALDH1A1 (0.47) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL9629748 | 0.81 | ALDH1A1 (0.47) | ALOX15ALDH1A1KMT2AFNTAFNTB | |
| SCHEMBL3400313 | 0.80 | KMT2A (0.65) | ALOX15ALDH1A1KMT2AFNTAFNTB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0418814-A2 | Isoprenoid phosphinylformic acid squalene synthetase inhibitors and method for preparing the same | E.R. SQUIBB & SONS, INC. (US) | 1991-03-27 | — | — | EP | claimed |
| US-5166386-A | Inhibit cholesterol biosynthesis | E. R. SQUIBB & SONS, INC. (US) | 1992-11-24 | — | — | US | disclosed |
| US-5107011-A | Intermediates for anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-04-21 | — | — | US | disclosed |
| US-5025003-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1991-06-18 | — | — | US | disclosed |
| EP-0418814-A2 | Isoprenoid phosphinylformic acid squalene synthetase inhibitors and method for preparing the same | E.R. SQUIBB & SONS, INC. (US) | 1991-03-27 | — | — | EP | disclosed |