Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 9/20 | 0.60 |
| ▸ | RAB9A | P51151 | 7/20 | 0.60 |
| ▸ | MAPT | P10636 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | POLB | P06746 | 2/20 | 0.56 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | AR | P10275 | 1/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.54 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.54 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9630876 | 0.85 | RAB9A (0.77) | NPC1RAB9AMAPTKMT2APOLB | |
| SCHEMBL22856757 | 0.77 | HTT (0.47) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL24141510 | 0.74 | NPC1 (0.61) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL22856758 | 0.74 | NPC1 (0.54) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL12442506 | 0.73 | MAPT (0.76) | NPC1RAB9AMAPTKMT2AALDH1A1 | |
| SCHEMBL12443358 | 0.72 | NPC1 (0.75) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL12443393 | 0.72 | NPC1 (0.75) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL8880979 | 0.72 | POLB (0.51) | KMT2AMEN1POLBGAACYP1A2 | |
| SCHEMBL9630236 | 0.71 | NPC1 (0.45) | NPC1RAB9AMAPTKMT2AMEN1 | |
| SCHEMBL10770200 | 0.71 | NPC1 (0.51) | NPC1RAB9AMAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5153210-A | Hypoglycemic agent, animal growth regulator; veterinary medicine | BEECHAM GROUP P.L.C. (GB) | 1992-10-06 | — | — | US | disclosed |
| EP-0236624-A2 | Substituted phenyl ethanol amines, processes for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1987-09-16 | — | — | EP | disclosed |