Known targets — ChEMBL curated mechanism
CHRM1DRD2DRD3DRD4HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HTR2APDE3ASIGMAR1SLC9A3
The experimentally established mechanism targets of L-Lactic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC22A1 | O15245 | 3/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.50 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.48 |
| ▸ | DNM1 | Q05193 | 4/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| L-Lactic Acid SCHEMBL29256387 | 0.98 | SLC22A1 (0.54) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Tetrabuthylammonium SCHEMBL331981 | 0.96 | SLC22A1 (0.52) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Tetrabuthylammonium SCHEMBL30104046 | 0.96 | SLC22A1 (0.52) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Tetrabuthylammonium SCHEMBL2398988 | 0.94 | SLC22A1 (0.50) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Tetrabuthylammonium SCHEMBL2398990 | 0.94 | SLC22A1 (0.50) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| Cadaverine Tartrate SCHEMBL9094501 | 0.88 | SLC22A1 (0.52) | SLC22A1ALDH1A1TP53CYP3A4ALOX15 | |
| L-Lactic Acid SCHEMBL5570478 | 0.86 | DNM1 (0.58) | TSHRSMN1; SMN2HSD17B10CA1DNM1 | |
| L-Lactic Acid SCHEMBL9632141 | 0.86 | DNM1 (0.58) | TSHRSMN1; SMN2HSD17B10CA1DNM1 | |
| L-Lactic Acid SCHEMBL5574997 | 0.86 | CA1 (0.47) | CA1DNM1CA2 | |
| L-Lactic Acid SCHEMBL5570547 | 0.86 | DNM1 (0.58) | TSHRSMN1; SMN2HSD17B10CA1DNM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5091350-A | Extracting with aqueous solution of organic phosphine sulfonate or carboxylate and solubilizer | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-25 | — | — | US | disclosed |
| US-4731485-A | Process for hydroformylation with rhodium catalysts and the separation of rhodium therefrom | RUHRCHEMIE AKTIENGESELLSCHAFT (DE) | 1988-03-15 | — | — | US | disclosed |