Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 8/20 | 0.40 |
| ▸ | KDR | P35968 | 5/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.40 |
| ▸ | RET | P07949 | 4/20 | 0.40 |
| ▸ | FLT3 | P36888 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.40 |
| ▸ | FLT1 | P17948 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.40 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.40 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | FYN | P06241 | 1/20 | 0.40 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14036942 | 0.68 | ALDH1A1 (0.43) | ALDH1A1PDPK1KDRPDGFRBRET | |
| SCHEMBL10141196 | 0.66 | — | — | |
| SCHEMBL22163881 | 0.66 | — | — | |
| SCHEMBL10141206 | 0.66 | — | — | |
| SCHEMBL19596 | 0.66 | — | — | |
| SCHEMBL30027844 | 0.65 | ALDH1A1 (0.49) | ALDH1A1PDPK1KDRPDGFRBRET | |
| SCHEMBL12866850 | 0.65 | ALDH1A1 (0.38) | ALDH1A1PDPK1KDRPDGFRBRET | |
| SCHEMBL79995 | 0.65 | ALDH1A1 (0.38) | ALDH1A1PDPK1KDRPDGFRBRET | |
| SCHEMBL559603 | 0.65 | GRIN2D (0.45) | ALDH1A1PDPK1KDRPDGFRBRET | |
| SCHEMBL2464131 | 0.65 | MAPT (0.52) | ALDH1A1PDPK1KDRPDGFRBRET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5136049-A | Reacting a heterocyclic-containing ketone, aldehyde, acyl halide or ester and 3-sulfolane, 1,3-dihydrobenzothiophene, naphtho(2,3-c)furan or thiophene or phenanthra(9,10-c)furan or thiophene | WACKER-CHEMIE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |