Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GBA1 | P04062 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | THRB | P10828 | 1/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | MGLL | Q99685 | 4/20 | 0.37 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.37 |
| ▸ | FAAH | O00519 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | PLA2G2A | P14555 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | G6PD | P11413 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9704737 | 0.98 | GBA1 (0.45) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL9705943 | 0.94 | MEN1 (0.39) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL5983248 | 0.89 | GBA1 (0.41) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL5981877 | 0.87 | GBA1 (0.43) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL993043 | 0.86 | — | — | |
| SCHEMBL5983122 | 0.83 | MEN1 (0.37) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL5621142 | 0.77 | — | — | |
| SCHEMBL5982960 | 0.74 | KMT2A (0.35) | ALDH1A1GAAMAPTMEN1KMT2A | |
| SCHEMBL5535564 | 0.74 | ALDH1A1 (0.41) | GBA1ALDH1A1GAAMAPTTHRB | |
| SCHEMBL8392599 | 0.74 | ITGB3 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162523-A | CEPHALOSPORIN ANTIBACTERIAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5159077-A | Bactericide, antibiotic | HOFFMANN-LA ROCHE INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0470543-A1 | Heterocyclic imidazoles, remedies containing them and processes for their preparation | Dr. Karl Thomae GmbH (DE) | 1992-02-12 | — | — | EP | disclosed |
| EP-0409081-A1 | Beta-Lactam Derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-23 | — | — | EP | disclosed |
| EP-0085291-B1 | 2-OXO-1-(AMINOCARBONYLAMINOSULFONYLAMINOCARBONYL)AZETIDINES | E.R. Squibb & Sons, Inc. (US) | 1988-08-17 | — | — | EP | disclosed |
| US-4670553-A | 2-oxo-1-(aminocarbonylaminosulfonyl-aminocarbonyl)azetidines | E. R. SQUIBB & SONS, INC. (US) | 1987-06-02 | — | — | US | disclosed |
| EP-0085291-A1 | 2-Oxo-1-(aminocarbonylaminosulfonylaminocarbonyl)azetidines | E.R. Squibb & Sons, Inc. (US) | 1983-08-10 | — | — | EP | disclosed |