Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.41 |
| ▸ | NPC1 | O15118 | 7/20 | 0.41 |
| ▸ | RAB9A | P51151 | 7/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | ATAD2 | Q6PL18 | 1/20 | 0.37 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.37 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CASP3 | P42574 | 1/20 | 0.36 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9631728 | 0.81 | APEX1 (0.37) | SMN1; SMN2MAPTKMT2AMAPK1APEX1 | |
| SCHEMBL9633136 | 0.80 | NPSR1 (0.55) | SMN1; SMN2NPC1RAB9AL3MBTL1NPSR1 | |
| SCHEMBL9631803 | 0.80 | APEX1 (0.36) | APEX1 | |
| SCHEMBL9631760 | 0.80 | APEX1 (0.36) | L3MBTL1APEX1 | |
| SCHEMBL9633107 | 0.74 | GLA (0.34) | SMN1; SMN2NPC1RAB9AMAPTKMT2A | |
| SCHEMBL10364751 | 0.73 | KMT2A (0.52) | NPSR1HPGDMAPTNOTUMMEN1 | |
| SCHEMBL10363686 | 0.72 | LMNA (0.57) | SMN1; SMN2NPC1RAB9AHPGDMAPT | |
| SCHEMBL10363086 | 0.72 | APEX1 (0.59) | SMN1; SMN2NPC1L3MBTL1NPSR1KMT2A | |
| SCHEMBL10363209 | 0.70 | SMN1; SMN2 (0.45) | SMN1; SMN2NPC1RAB9AL3MBTL1NPSR1 | |
| SCHEMBL20506744 | 0.68 | APEX1 (0.46) | SMN1; SMN2NPC1RAB9AL3MBTL1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162349-A | Mercaptobis/1,3,4-oxa- and -thiadiazoles/ | CIBA-GEIGY CORPORATION (US) | 1992-11-10 | — | — | US | claimed |
| EP-0364396-A1 | Neumaticides and fungicides | CIBA-GEIGY AG (CH) | 1990-04-18 | — | — | EP | claimed |
| US-5162349-A | Mercaptobis/1,3,4-oxa- and -thiadiazoles/ | CIBA-GEIGY CORPORATION (US) | 1992-11-10 | — | — | US | disclosed |
| EP-0364396-A1 | Neumaticides and fungicides | CIBA-GEIGY AG (CH) | 1990-04-18 | — | — | EP | disclosed |