SCHEMBL9633287

SCHEMBL9633287

CCO[Si](C)(Cl)c1ccccc1

nearest known ligand 0.34

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
TP53 P04637 2/20 0.33
ALDH1A1 P00352 2/20 0.33
KDM4E B2RXH2 1/20 0.33
NPC1 O15118 1/20 0.33
HPGD P15428 1/20 0.33
RAB9A P51151 1/20 0.33
SMN1; SMN2 Q16637 1/20 0.33
TSHR P16473 1/20 0.33
LTA4H P09960 1/20 0.33
ELANE P08246 1/20 0.32
MAPT P10636 2/20 0.32
POLB P06746 1/20 0.32
LMNA P02545 2/20 0.31
CHRNB2 P17787 1/20 0.31
CHRNB4 P30926 1/20 0.31
CHRNA3 P32297 1/20 0.31
CHRNA7 P36544 1/20 0.31
CHRNA4 P43681 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4071553 0.80 LTA4H (0.34) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL9499334 0.80 LTA4H (0.34) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL1130609 0.80 LTA4H (0.34) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL9654851 0.77 ESR1 (0.37) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL242577 0.77 MAPT (0.37) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL27670640 0.77 ESR1 (0.37) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL103755 0.77 ESR1 (0.37) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL106512 0.77 ESR1 (0.37) ESR1ESR2TP53ALDH1A1KDM4E
SCHEMBL18108289 0.77 LTA4H (0.32) TP53LTA4H
SCHEMBL18108006 0.77 LTA4H (0.32) TP53LTA4HMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-9884928-B2 Polymers functionalized with activated nitrogen heterocycles containing a pendant functional group BRIDGESTONE CORPORATION (JP) 2018-02-06 US disclosed
US-20160289354-A1 POLYMERS FUNCTIONALIZED WITH ACTIVATED NITROGEN HETEROCYCLES CONTAINING A PENDANT FUNCTIONAL GROUP BRIDGESTONE CORPORATION (JP) 2016-10-06 US disclosed
EP-0210452-B1 PROCESS FOR THE PREPARATION OF PARTIALLY ESTERIFIED SILICON HALIDES HÜLS AKTIENGESELLSCHAFT (DE) 1992-05-06 EP disclosed
US-4677215-A Method of preparing partially esterified silicon halides DYNAMIT NOBEL AG (DE) 1987-06-30 US disclosed
EP-0210452-A2 Process for the preparation of partially esterified silicon halides HÜLS AKTIENGESELLSCHAFT (DE) 1987-02-04 EP disclosed