Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 4/20 | 0.44 |
| ▸ | CYP4A11 | Q02928 | 4/20 | 0.44 |
| ▸ | PLAU | P00749 | 1/20 | 0.37 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.37 |
| ▸ | HMGCR | P04035 | 1/20 | 0.36 |
| ▸ | LPL | P06858 | 2/20 | 0.36 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.36 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.35 |
| ▸ | SLC9A3 | P48764 | 1/20 | 0.35 |
| ▸ | SLC9A2 | Q9UBY0 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | MEF2D | Q14814 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633367 | 0.85 | HMGCR (0.36) | CYP4F2CYP4A11HMGCRLPLLIPG | |
| SCHEMBL9631997 | 0.82 | SQLE (0.43) | CYP4F2CYP4A11 | |
| SCHEMBL9632012 | 0.82 | SQLE (0.43) | CYP4F2CYP4A11 | |
| SCHEMBL23648072 | 0.79 | CYP4F2 (0.43) | CYP4F2CYP4A11PLAUTBXA2RLPL | |
| SCHEMBL1246800 | 0.79 | CYP4F2 (0.46) | CYP4F2CYP4A11PLAUTBXA2RLTA4H | |
| SCHEMBL9632936 | 0.78 | CYP4A11 (0.44) | CYP4F2CYP4A11LTA4HEPHX2 | |
| SCHEMBL9633674 | 0.77 | KEAP1 (0.52) | LIPG | |
| SCHEMBL241880 | 0.77 | CYP4F2 (0.53) | CYP4F2CYP4A11TBXA2RLPLLIPG | |
| SCHEMBL1554030 | 0.77 | SLC9A1 (0.48) | SLC9A1SLC9A3SLC9A2 | |
| SCHEMBL9455027 | 0.77 | SLC9A1 (0.41) | CYP4F2CYP4A11SLC9A1SLC9A3SLC9A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |