Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | FDPS | P14324 | 8/20 | 0.57 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.40 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9569187 | 0.92 | BLM (0.53) | LMNAFDPSBLMGGPS1PTPN1 | |
| SCHEMBL20058314 | 0.89 | FDPS (0.68) | FDPSGGPS1 | |
| SCHEMBL20582647 | 0.81 | LMNA (0.54) | LMNAFDPSBLMPTPN1MEN1 | |
| SCHEMBL2398165 | 0.81 | LMNA (0.54) | LMNAFDPSBLMPTPN1MEN1 | |
| SCHEMBL8915245 | 0.80 | FDPS (0.45) | LMNAFDPSBLMGGPS1PTPN1 | |
| SCHEMBL20699855 | 0.79 | FDPS (0.75) | FDPS | |
| SCHEMBL2321372 | 0.79 | FDPS (0.70) | FDPS | |
| SCHEMBL12570893 | 0.77 | FDPS (0.59) | FDPSGGPS1 | |
| SCHEMBL10863085 | 0.77 | FDPS (0.76) | FDPS | |
| Squalane SCHEMBL4708649 | 0.76 | LMNA (1.00) | LMNABLMPTPN1MEN1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | claimed |
| EP-0513761-A2 | Bisphosphonate squalene synthetase inhibitors | E.R. SQUIBB & SONS, INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5157027-A | Anticholesterol agents | E. R. SQUIBB & SONS, INC. (US) | 1992-10-20 | — | — | US | disclosed |