Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | STAT3 | P40763 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.44 |
| ▸ | HPGD | P15428 | 5/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636784 | 0.86 | KDM4E (0.76) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL9635375 | 0.83 | KDM4E (0.62) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL9636861 | 0.81 | KDM4E (0.71) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL11187032 | 0.81 | KDM4E (0.55) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL11185195 | 0.81 | KDM4E (0.54) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL5258333 | 0.79 | STAT3 (0.62) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL9635338 | 0.78 | KDM4E (0.58) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL11235862 | 0.77 | STAT3 (0.54) | KDM4EKMT2ASTAT3ALDH1A1HPGD | |
| SCHEMBL13576353 | 0.77 | KDM4E (0.79) | KDM4EKMT2AALDH1A1HPGDHSD17B10 | |
| SCHEMBL11182877 | 0.77 | KDM4E (0.53) | KDM4EKMT2ASTAT3ALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5162523-A | CEPHALOSPORIN ANTIBACTERIAL COMPOUNDS | HOFFMANN-LA ROCHE INC. (US) | 1992-11-10 | — | — | US | disclosed |
| US-5159077-A | Bactericide, antibiotic | HOFFMANN-LA ROCHE INC. (US) | 1992-10-27 | — | — | US | disclosed |
| EP-0409081-A1 | Beta-Lactam Derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1991-01-23 | — | — | EP | disclosed |