Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G4A | P47712 | 12/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.41 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.41 |
| ▸ | LTB4R | Q15722 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633663 | 0.92 | MTNR1A (0.38) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9633747 | 0.83 | EPHX2 (0.53) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9634171 | 0.81 | PLA2G4A (0.53) | PLA2G4ALTB4R | |
| SCHEMBL9635044 | 0.78 | CYSLTR2 (0.39) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9634970 | 0.76 | NQO2 (0.49) | PLA2G4ALTB4R | |
| SCHEMBL9634717 | 0.76 | PLA2G4A (0.51) | PLA2G4ALTB4R | |
| SCHEMBL9633815 | 0.76 | CYSLTR2 (0.69) | CYSLTR2CYSLTR1 | |
| SCHEMBL9825747 | 0.74 | CYSLTR1 (0.48) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9555865 | 0.74 | PLA2G4A (0.53) | PLA2G4ACYSLTR2CYSLTR1LTB4R | |
| SCHEMBL8901038 | 0.74 | EPHX2 (0.41) | PLA2G4ACYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |