Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 8/20 | 0.38 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.37 |
| ▸ | C5AR1 | P21730 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.37 |
| ▸ | DRD3 | P35462 | 1/20 | 0.37 |
| ▸ | PLA2G4A | P47712 | 2/20 | 0.37 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.35 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9633828 | 0.92 | PLA2G4A (0.45) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9633747 | 0.84 | EPHX2 (0.53) | NR1H4PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9825747 | 0.82 | CYSLTR1 (0.48) | NR1H4PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9825015 | 0.80 | CYSLTR2 (0.58) | PLA2G4ACYSLTR2CYSLTR1 | |
| SCHEMBL9634219 | 0.78 | MEN1 (0.35) | MTNR1AMTNR1BNQO2CYSLTR2CYSLTR1 | |
| SCHEMBL10969445 | 0.78 | KDM4E (0.50) | NR1H4 | |
| SCHEMBL9634970 | 0.77 | NQO2 (0.49) | MTNR1AMTNR1BNQO2PLA2G4A | |
| SCHEMBL9633776 | 0.77 | NQO2 (0.44) | MTNR1AMTNR1BNQO2 | |
| SCHEMBL9633653 | 0.77 | CYSLTR2 (0.60) | CYSLTR2CYSLTR1 | |
| SCHEMBL9633804 | 0.77 | NQO2 (0.48) | MTNR1AMTNR1BNQO2PLA2G4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0337765-B1 | ACYLSULFONAMIDE DERIVATIVES OF ALPHA-CARBOCYCLYLTOLUIC ACIDS USED AS LEUKOTRIENE ANTAGONISTS | ICI AMERICAS INC. (US) | 1992-10-14 | — | — | EP | disclosed |
| US-5095038-A | Antiinflammatory, antiallergens | ICI AMERICAS INC. (US) | 1992-03-10 | — | — | US | disclosed |
| EP-0337765-A2 | Acylsulfonamide derivatives of alpha-carbocyclyltoluic acids used as leukotriene antagonists | ICI AMERICAS INC. (US) | 1989-10-18 | — | — | EP | disclosed |