Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.64 |
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.44 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 3/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | NR1D1 | P20393 | 2/20 | 0.42 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.41 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL856088 | 0.87 | NR3C1 (0.47) | CYP3A4POLBALDH1A1SMN1; SMN2NR3C1 | |
| SCHEMBL10558022 | 0.76 | CYP3A4 (0.83) | CYP3A4PKMCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL10560245 | 0.76 | CYP3A4 (0.67) | CYP3A4 | |
| SCHEMBL10986334 | 0.75 | MAPK1 (0.49) | CYP3A4CHRNB2CHRNA4TP53POLB | |
| SCHEMBL10561478 | 0.75 | CYP3A4 (0.65) | CYP3A4PKMCHRNB2CHRNA4ALDH1A1 | |
| SCHEMBL10557482 | 0.75 | CYP3A4 (0.62) | CYP3A4PKM | |
| SCHEMBL10980502 | 0.74 | CHRNB2 (0.49) | CYP3A4CHRNB2CHRNA4NR1D1NR1H3 | |
| SCHEMBL10622592 | 0.73 | CYP3A4 (0.47) | CYP3A4PKMCHRNB2CHRNA4TP53 | |
| SCHEMBL9288362 | 0.72 | CYP3A4 (0.54) | CYP3A4CHRNB2CHRNA4TP53NR1H3 | |
| SCHEMBL10561440 | 0.71 | CYP3A4 (0.58) | CYP3A4PKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0516278-A1 | Use of anti-mullerian hormone for reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | claimed |
| EP-0514015-A1 | Control of sex differentiation in fish | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | claimed |
| US-5162337-A | Administering Steroid Biosynthesis Inhibitors | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | claimed |
| WO-1992018132-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA COMTAINING A 5 ALPHA-REDUCTASE INHIBITOR | MERCK & CO., INC. (US) | 1992-10-29 | — | — | WO | claimed |
| EP-0479570-A2 | Animal growth promotion with aromatase inhibitors | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | claimed |
| EP-0433084-A2 | Use of aromatese inhibitors for the reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | claimed |
| US-4774251-A | PYRIDINE ALKYLAMINES OR PYRAZINE ALKYLAMINE DERIVATIVRES | ELI LILLY AND COMPANY (US) | 1988-09-27 | — | — | US | claimed |
| US-4552960-A | N,N-DISUBSTITUTED HETEROCYCLIC AMINES | ELI LILLY AND COMPANY (US) | 1985-11-12 | — | — | US | claimed |
| EP-0129433-A2 | Amines as fungicidal agents | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | claimed |
| EP-0516278-A1 | Use of anti-mullerian hormone for reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1992-12-02 | — | — | EP | disclosed |
| EP-0514015-A1 | Control of sex differentiation in fish | MERCK & CO. INC. (US) | 1992-11-19 | — | — | EP | disclosed |
| US-5162337-A | Administering Steroid Biosynthesis Inhibitors | MERCK & CO., INC. (US) | 1992-11-10 | — | — | US | disclosed |
| WO-1992018132-A1 | PHARMACEUTICAL COMBINATION FOR THE TREATMENT OF BENIGN PROSTATIC HYPERPLASIA COMTAINING A 5 ALPHA-REDUCTASE INHIBITOR | MERCK & CO., INC. (US) | 1992-10-29 | — | — | WO | disclosed |
| EP-0479570-A2 | Animal growth promotion with aromatase inhibitors | MERCK & CO. INC. (US) | 1992-04-08 | — | — | EP | disclosed |
| EP-0433084-A2 | Use of aromatese inhibitors for the reversal of female sexual phenotype in poultry | MERCK & CO. INC. (US) | 1991-06-19 | — | — | EP | disclosed |
| US-4552960-A | N,N-DISUBSTITUTED HETEROCYCLIC AMINES | ELI LILLY AND COMPANY (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0129433-A2 | Amines as fungicidal agents | ELI LILLY AND COMPANY (US) | 1984-12-27 | — | — | EP | disclosed |