Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Oxalic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A9 | P48067 | 1/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.47 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.47 |
| ▸ | HRH1 | P35367 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 2/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9636330 | 0.95 | SLC6A9 (0.68) | SLC6A9KDM4EPOLBTSHRCHRM5 | |
| Oxalic Acid SCHEMBL9870156 | 0.91 | SLC6A9 (0.66) | SLC6A9KDM4ECHRM5CHRM1MEN1 | |
| Oxalic Acid SCHEMBL9870147 | 0.91 | SLC6A9 (0.66) | SLC6A9KDM4ECHRM5CHRM1MEN1 | |
| Oxalic Acid SCHEMBL9636289 | 0.89 | SLC6A9 (0.63) | SLC6A9KDM4ETSHRCHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9636284 | 0.89 | SLC6A9 (0.61) | SLC6A9KDM4ETSHRCHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9636294 | 0.89 | SLC6A9 (0.63) | SLC6A9KDM4ETSHRCHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9634849 | 0.88 | SLC6A9 (0.61) | SLC6A9KDM4ECHRM5CHRM1MEN1 | |
| Oxalic Acid SCHEMBL9634855 | 0.88 | SLC6A9 (0.61) | SLC6A9KDM4ECHRM5CHRM1MEN1 | |
| Oxalic Acid SCHEMBL9634632 | 0.88 | SLC6A9 (0.60) | SLC6A9KDM4EPOLBCHRM5CHRM1 | |
| Oxalic Acid SCHEMBL9636288 | 0.88 | SLC6A9 (0.60) | SLC6A9KDM4ECHRM5CHRM1HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0307014-B1 | ANTI-ALLERGIC 2-(HETEROCYCLYL ALKYL) IMIDAZO PYRIDINES AND 2-(HETEROCYCLYL ALKYL) PURINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-12-09 | — | — | EP | disclosed |
| US-5086056-A | Treating allergic diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-04 | — | — | US | disclosed |
| US-5011842-A | Antihistamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1991-04-30 | — | — | US | disclosed |
| US-4946843-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1990-08-07 | — | — | US | disclosed |
| EP-0307014-A1 | Anti-allergic 2-(heterocyclyl alkyl) imidazo pyridines and 2-(heterocyclyl alkyl) purines | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-03-15 | — | — | EP | disclosed |