Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 7/20 | 0.61 |
| ▸ | TMEM97 | Q5BJF2 | 6/20 | 0.61 |
| ▸ | HRH2 | P25021 | 3/20 | 0.61 |
| ▸ | HRH1 | P35367 | 3/20 | 0.61 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.61 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.61 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.61 |
| ▸ | HTR2A | P28223 | 2/20 | 0.58 |
| ▸ | HTR1A | P08908 | 1/20 | 0.58 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.58 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.58 |
| ▸ | HTR1B | P28222 | 1/20 | 0.58 |
| ▸ | HTR2C | P28335 | 1/20 | 0.58 |
| ▸ | HTR1E | P28566 | 1/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.58 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.55 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.54 |
| ▸ | HTR7 | P34969 | 1/20 | 0.54 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29234166 | 0.89 | HTT (0.56) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL21906828 | 0.87 | L3MBTL1 (0.67) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL4904424 | 0.86 | SIGMAR1 (0.57) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL9633964 | 0.86 | MEN1 (0.57) | SIGMAR1TMEM97HRH2HRH1HTR2A | |
| SCHEMBL29207863 | 0.86 | SIGMAR1 (0.52) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL29234309 | 0.86 | HTT (0.55) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL5551353 | 0.85 | KDM4E (0.62) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL27629467 | 0.85 | SIGMAR1 (0.56) | SIGMAR1TMEM97HRH2HRH1HTR2A | |
| SCHEMBL19510869 | 0.85 | KDM4E (0.62) | SIGMAR1TMEM97HRH2HRH1SLC6A2 | |
| SCHEMBL7658562 | 0.84 | L3MBTL1 (0.68) | L3MBTL1NPC1RAB9ASMN1; SMN2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0166509-B1 | PHENOL DERIVATIVES | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1992-05-13 | — | — | EP | disclosed |
| US-4833135-A | Antioestrogenic phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1989-05-23 | — | — | US | disclosed |
| EP-0166509-A1 | Phenol derivatives | IMPERIAL CHEMICAL INDUSTRIES PLC (GB) | 1986-01-02 | — | — | EP | disclosed |