Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 6/20 | 0.56 |
| ▸ | PDE5A | O76074 | 4/20 | 0.52 |
| ▸ | PDE2A | O00408 | 1/20 | 0.51 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.47 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.46 |
| ▸ | PARP1 | P09874 | 2/20 | 0.46 |
| ▸ | PRMT5 | O14744 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | ATM | Q13315 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9635658 | 0.96 | AURKA (0.56) | AURKAPDE5APDE2ATHRBKDM4E | |
| SCHEMBL9634857 | 0.90 | PDE5A (0.55) | AURKAPDE5APDE2ANPY5RPRMT5 | |
| SCHEMBL9635725 | 0.90 | PDE5A (0.55) | AURKAPDE5APDE2ANPY5RPRMT5 | |
| SCHEMBL9636135 | 0.88 | AURKA (0.54) | AURKAPDE5APDE2ATHRBKDM4E | |
| SCHEMBL9634352 | 0.85 | AURKA (0.48) | AURKAPDE5ANPY5RPARP1PRMT5 | |
| SCHEMBL9634821 | 0.85 | PARP1 (0.49) | AURKAPDE5APDE2ANPY5RPARP1 | |
| SCHEMBL9634875 | 0.82 | PDE5A (0.57) | AURKAPDE5APDE2AKDM4EALDH1A1 | |
| SCHEMBL9634270 | 0.81 | PDE2A (0.61) | AURKAPDE5APDE2AKDM4EALDH1A1 | |
| SCHEMBL9634619 | 0.81 | PDE2A (0.65) | AURKAPDE5APDE2AKDM4EALDH1A1 | |
| SCHEMBL9634492 | 0.81 | AURKA (0.63) | AURKAPDE5APDE2AKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5104881-A | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1992-04-14 | — | — | US | disclosed |
| US-4616090-A | 2-arylimidazopyridines intermediates | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1986-10-07 | — | — | US | disclosed |
| EP-0072926-B1 | 2-ARYLIMIDAZOPYRIDINES | MERCK PATENT GmbH (DE) | 1986-09-24 | — | — | EP | disclosed |
| EP-0072926-A1 | 2-Arylimidazopyridines | MERCK PATENT GmbH (DE) | 1983-03-02 | — | — | EP | disclosed |